Categories: Uncategorized

Women itch less than males: Research

According to a study performed by a team of experts at Kyoto University, human females have a considerably lower incidence of severe psoriasis and hence itch less, which is one of many things that men may be jealous of, at least when it comes to severe skin inflammation.

Hormone that lowers itching

The study’s findings were published in the ‘Journal of Allergy and Clinical Immunology.’ Now, a team of researchers has discovered that the female hormone estradiol lowers itching, and the hormone’s protective effect has created a foundation for its therapeutic potential.

“Our findings not only showed the molecular causes of sex differences in itching, but also shed fresh light on our knowledge of the physiological role of estradiol,” explains Tetsuya Honda, previously of Kyoto University.

The researchers used conditional knockout mice, or cko mice, that had their ovaries removed but were given estradiol pellets or a placebo. Compared to wild-type mice, cko animals lacking the natural ovarian hormone estradiol displayed significant skin irritation.

Also Read: Researchers develop self-powered smart implants to monitor spinal fusion recovery

When these animals were administered estradiol, the synthesis of cytokines IL-17A and IL-1b in neutrophil and macrophage immune cells was reversed, resulting in reduced inflammation. In vitro, same impact was also demonstrated in human neutrophils.

The researchers were interested by how the lack of oestrogen receptors in immune cells rendered estradiol ineffective against the cytokines.

“These findings suggest that estradiol lowers psoriatic inflammation through controlling neutrophil and macrophage cells,” the author writes.

Follow Medically Speaking on Instagram
Medically Speaking

Recent Posts

ANTIBIOTIC MISUSE IN INDIA: HOW IT’S MAKING INFECTION TREATMENT MORE CHALLENGING

Antibiotic use has surged globally, leading to a rise in antibiotic resistance, especially concerning in…

6 hours ago

CHILD DIES FROM CHOKING ON CANDY: HOW TO SAFEGUARD AGAINST CHOKING HAZARDS IN YOUNG CHILDREN

Choking is a leading cause of injury and death in young children, particularly those under…

8 hours ago

Video: How Hard Water Leads to Hair Fall and Expert Tips to Combat It

Hard Water (Khara Pani) Leading To Hair Fall Hard water is rich in minerals and…

9 hours ago

“How High Blood Pressure During Pregnancy Is Rising: What Every Expectant Mother Should Know”

Discover how the rise in high blood pressure during pregnancy is impacting maternal and fetal…

9 hours ago

“Revitalize Your Weight Loss Journey: 6 Powerful Homemade Drinks to Naturally Melt Away Fat!”

"Discover the transformative power of six delicious homemade drinks that can help you naturally melt…

10 hours ago

“Revitalize Your Weight Loss Journey: 8 Powerful Fat-Flushing Drinks to Boost Your Results!”

"Transform your weight loss routine with these eight delicious fat-flushing drinks that not only hydrate…

10 hours ago