Why the Omicron variant causes less severe disease

A new study by researchers from the University of Kent and the Goethe University Frankfurt shows that the SARS-CoV-2 Omicron variant is less effective than Delta at blocking a cellular defence mechanism against viruses, the so-called “interferon response.” Moreover, cell culture findings indicate that eight important COVID-19 drugs and drug candidates remain effective against Omicron.

The SARS-CoV-2 Omicron variant causes less severe disease than Delta although it is better at escaping immune protection by vaccinations and previous infections. The reasons for this have so far remained elusive.

A new study by a research team with scientists from the University of Kent and the Goethe-University Frankfurt has now shown that Omicron variant viruses are particularly sensitive to inhibition by the so-called interferon response, an unspecific immune response that is present in all body cells. This provides the first explanation of why COVID-19 patients infected with the Omicron variant are less likely to experience severe disease.

The cell culture study also showed that Omicron viruses remain sensitive to eight of the most important antiviral drugs and drug candidates for the treatment of COVID-19. This included: EIDD-1931 (active metabolite of molnupiravir), ribavirin, remdesivir, favipravir, PF-07321332 (nirmatrelvir, active ingredient of paxlovid), nafamostat, camostat, and aprotinin.

Prof Martin Michaelis, School of Bioscience, University of Kent, said: “Our study provides for the first time an explanation, why Omicron infections are less likely to cause severe disease. This is due to Omicron, in contrast to Delta, does not effectively inhibit the host cell interferon immune response.”

Prof. Jindrich Cinatl, Institute of Medical Virology at the Goethe-University, added: “Although cell culture experiments do not exactly reflect the more complex situation in a patient, our data provide encouraging evidence that the available antiviral COVID-19 drugs are also effective against Omicron.”

Source: Goethe University Frankfurt

Medically Speaking Team

Recent Posts

ANTIBIOTIC MISUSE IN INDIA: HOW IT’S MAKING INFECTION TREATMENT MORE CHALLENGING

Antibiotic use has surged globally, leading to a rise in antibiotic resistance, especially concerning in…

6 hours ago

CHILD DIES FROM CHOKING ON CANDY: HOW TO SAFEGUARD AGAINST CHOKING HAZARDS IN YOUNG CHILDREN

Choking is a leading cause of injury and death in young children, particularly those under…

8 hours ago

Video: How Hard Water Leads to Hair Fall and Expert Tips to Combat It

Hard Water (Khara Pani) Leading To Hair Fall Hard water is rich in minerals and…

9 hours ago

“How High Blood Pressure During Pregnancy Is Rising: What Every Expectant Mother Should Know”

Discover how the rise in high blood pressure during pregnancy is impacting maternal and fetal…

9 hours ago

“Revitalize Your Weight Loss Journey: 6 Powerful Homemade Drinks to Naturally Melt Away Fat!”

"Discover the transformative power of six delicious homemade drinks that can help you naturally melt…

10 hours ago

“Revitalize Your Weight Loss Journey: 8 Powerful Fat-Flushing Drinks to Boost Your Results!”

"Transform your weight loss routine with these eight delicious fat-flushing drinks that not only hydrate…

10 hours ago