A common antidepressant should not be used to treat dementia patients, according to a new study

According to a new study, a medicine used to treat agitation in patients with dementia is no more beneficial than a placebo and may potentially increase mortality. The study, headed by the University of Plymouth and published in The Lancet, found that the antidepressant mirtazapine had no effect on agitation in persons with deMENTIA and was perhaps more likely to be linked to death than no intervention at all.
Agitation is a frequent sign of dementia that is marked by excessive verbal, vocal, or motor activity, as well as physical and verbal hostility. The primary solution should be non-drug patient-centered treatment, but if that doesn’t work, physicians may turn to a drug-based option.

Antipsychotics have proven to increase death rates in those with dementia, along with other poor outcomes, and so mirtazapine has been routinely prescribed. This study was designed to add to the evidence base around its effectiveness.

Funded by the National Institute for Health Research (NIHR), the study recruited 204 people with probable or possible Alzheimer’s disease from 20 sites around the UK, allocating half to mirtazapine and half to placebo. The trial was double-blind; meaning that neither the researcher nor the study participants knew what they were taking.

The results showed that there was no less agitation after 12 weeks in the mirtazapine group than in the control group. There were also more deaths in the mirtazapine group (seven) by week 16 than in the control group (only one), with analysis suggesting this was of marginal statistical significance.

Lead researcher Professor Sube Banerjee, Executive Dean of the Faculty of Health and Professor in Dementia at the University of Plymouth, explained why the results were so surprising but important.

“Dementia affects 46 million people worldwide – a figure set to double over the next 20 years. Poor life quality is driven by problems like agitation and we need to find ways to help those affected,” he said.

This study shows that a common way of managing symptoms is not helpful – and could even be detrimental. It’s really important that these results are taken into account and mirtazapine is no longer used to treat agitation in people with dementia.

“This study has added important information to the evidence base, and we look forward to investigating further treatments that may help to improve people’s quality of life,” Banerjee added.

Medically Speaking

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