‘New Covid-19 variant C.1.2 may evade vax protection’

According to a study, a novel variation of SARS-CoV-2, the virus that causes Covid-19, has been discovered in South Africa and many other locations around the world, which could be more transmissible and escape vaccine protection.

The probable variant of interest, C.1.2, was first found in South Africa in May this year, according to scientists from the National Institute for Communicable Diseases (NICD) and the KwaZulu-Natal Research Innovation and Sequencing Platform (KRISP).

C.1.2 has been found in China, the Democratic Republic of the Congo, Mauritius, England, New Zealand, Portugal and Switzerland as of August 13, they said.

According to the yet-to-be peer-reviewed study posted on the preprint repository MedRxiv on August 24, C.1.2 has mutated substantially compared to C.1, one of the lineages which dominated the SARS-CoV-2 infections in the first wave in South Africa.

The new variant has more mutations than other variants of concern (VOCs) or variants of interest (VOIs) detected worldwide so far, the researchers said.

They noted that the number of available sequences of C.1.2 may be an underrepresentation of the spread and frequency of the variant in South Africa and around the world. The study found consistent increases in the number of C.1.2 genomes in South Africa each month, rising from 0.2% of genomes sequenced in May to 1.6% in June and then to 2% in July.

“This is similar to the increases seen with the Beta and Delta variants in the country during early detection,” the authors of the study said. According to the study, C.1.2 lineage has a mutation rate of about 41.8 mutations per year, which is about twice as fast as the current global mutation rate of the other variants.