Study shows how early inhibitions fuel future depression

A new imaging research headed by a scientist at The University of Texas at Dallas revealed early risk factors related with children’s temperament, as well as a neural process that might predict whether a person would develop depression and anxiety during adolescence and early adulthood.

The study, published Oct. 26 in JAMA Psychiatry, followed a group of 165 people from the age of four months to the age of 26 between 1989 and 1993. Dr. Alva Tang, assistant professor of psychology in the School of Behavioral and Brain Sciences and the study’s corresponding author, discovered that people who are more inhibited in early childhood and who also do not respond typically to potential rewards as adolescents are more likely to develop depression later in life than anxiety.

“The findings highlight different mechanisms in the brain and relate them to who is at greater risk for developing different mental health issues,” said Tang, who conducted the research at the University of Maryland, College Park, before joining UT Dallas in August. “These results could inform the development of prevention-oriented treatments tailored to the individual.”

When babies are exposed to novel objects, people, or situations, some react positively and approach them without fear, whereas others respond with wariness or avoidance. This differentiation defines uninhibited versus inhibited behavior.

“We know that inhibited children are more likely to have anxiety disorders later, particularly social anxiety, that begins in late childhood to adolescence,” Tang said. “Less has been known about depression, which generally has a later onset, in young adulthood. But we do know that people who have had an anxiety disorder are 50% to 60% more likely to have depression later in life, so inhibited children should have higher risk for depression as well.”

Tang’s research is unique for its characterization of the subjects’ early temperamental risks and the protracted length of time they were studied.

“To show any relation with increases in depressive symptoms over time, we have to follow subjects for decades because full-blown syndromes usually do not emerge until young adulthood,” she said.

As young children, the subjects were categorized as either inhibited or uninhibited. As adolescents, they underwent functional MRIs while completing a task to measure their brains’ reaction in anticipating rewards — in this case, trying to win money.

“We looked at the ventral striatum, a brain region well studied in terms of understanding depression in adults, to see if it’s tied to maladaptive processing in the reward centers of the brain,” Tang said.

In response to potential monetary benefits, some study participants displayed a muted response in this brain region.

The researchers discovered that the link between inhibition from 14 to 24 months of age and increased depressive symptoms from 15 to 26 years of age was only present in those who also had reduced activity in the ventral striatum as adolescents. There was no such connection with anxiety.

“We found that behavioral inhibition was related to worsening depressive symptoms into adulthood. This supports the assertion that this temperament shows a stronger relation to developing anxiety in adolescence, but in adulthood, it is tied more strongly to depression. However, not all inhibited children develop anxiety or depression,” Tang said. “It was particularly the inhibited children who showed blunted striatal activity who were more likely to become more depressed in young adulthood.”

Tang said her past research has related anxiety to neural networks and processes subserving attention and executive functions, whereas the current work highlights reward and motivational centers in the brain related to depression.

“This study is new because it can separate different kinds of brain correlates for these different conditions,” she said.

Tang stated that there are already programs available for socially anxious and behaviorally inhibited youngsters that improve social and cognitive skills. Additional therapies for these children could address motivational impairments by teaching them how to deliberately create environments in which they can be socially engaged with peers and seek out pleasant experiences.

“This might in turn reduce the likelihood of developing depression that originates from being socially disengaged or missing out on opportunities for positive experiences,” she said.

She suggested that future research may look into the effectiveness of programs that target faulty reward processing in anxious teens in lowering the likelihood of later depression.

Anxiety and depression are complicated illnesses that can be triggered by a variety of reasons, including genetic, environmental, and other variables, according to Tang.

“Here, we show strong evidence that both early temperamental risk factors and maladaptive neurocognitive processing of rewards are involved in contributing to the development of depression.”

Also Read: Study finds autistic people are more vulnerable to depression, anxiety during pregnancy

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