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Discovers Endometriosis Diagnosis Without Surgery

by Medically Speaking March 30, 2022

written by Medically Speaking

Discovers Endometriosis Diagnosis Without Surgery

Endometriosis is an inflammatory disorder that occurs when tissue that typically borders the uterus develops outside of the uterus and onto other organs. According to the Office of Women’s Health, this illness affects more than 11% of women aged 15 to 44.

Menstrual cramps, pain during sex, intestinal issues, spotting, and infertility are some of the symptoms that patients may face. The exact cause is unknown, however it might be related to hereditary factors or immune system diseases.

“Initially, painful periods are not natural — there is still a stigma that women will endure. No, pain is never natural, therefore let’s do away with it “April Summerford, 36, said NBC New York.

During many visits to the doctor, she was assured she was normal and that she should just push through the discomfort. One doctor, in her experience, avoided diagnosing her with endometriosis just by recalling the statement, “I don’t want it to be endo because I can’t assist you.”

Summerford, a Fresno, Calif. native who has been battling infertility and the condition since she began her menstrual cycle as a teen, was one of over 1,800 women who took part in this research.

According to the American Society for Reproductive Medicine, 30 to 50 percent of endometriosis patients may have infertility.

“Because illness severity does not correlate with disease symptoms, you might have a very serious condition with very minor symptoms. Then there are many who have no symptoms at all and find about their illness during an infertility workup or even during a C-section “According to Dr. Christine Metz of NBC New York.

Dr. Metz is one of the study’s principal scientists at the Feinstein Institutes for Medical Research. She is also the co-director of Research OutSmarts Endometriosis (ROSE), an initiative that began in 2017.

The researchers investigated menstrual effluent as a non-invasive method of diagnosing the illness and discovered cells in the blood that might distinguish between healthy and sick people.

“We were truly pioneers in investigating menstrual effluent in any situation. It had not been well researched before to our involvement, and it was really mainly examined for regenerative medicine objectives since the endometrium regrows every month, which contains stem cells “Dr. Metz stated.

These discoveries take us one step closer to developing bearable medicines and reducing the time between symptoms and diagnosis.

“The single treatment developed in the previous 12 years, like all other medicines established thus far, is hormone-based, and none of them address the condition. They deal with pain “Dr. Metz said.

Women’s History Month and Endometriosis Awareness Month both fall in March. The team is now on the lookout for the next round of participants.

March 30, 2022 0 comment

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What Does Breast and Nipple Discharge Mean?

by Medically Speaking March 19, 2022

written by Medically Speaking

The appearance of nipple discharge might be disconcerting for women who aren’t nursing. There’s no need to be alarmed if you observe discharge from your breast. While nipple discharge might be dangerous, it’s usually harmless or caused by a small ailment.

Even if you are not breastfeeding, you should contact your doctor if you experience breast discharge. Your doctor will determine the best course of therapy based on your symptoms and the findings of diagnostic testing.

It’s never natural to have bloody nipple discharge. Nipple discharge from only one breast and discharge that happens spontaneously without anything touching, stimulating, or aggravating your breast are further symptoms of abnormalities.

The colour of the discharge isn’t typically useful in determining whether it’s normal or pathological. The colour of nipple discharge might be clear, yellow, white, or green in both pathological and normal cases.

What is the difference between normal and pathological nipple discharge?

When the nipples are pinched or squeezed, normal nipple discharge occurs more often in both nipples. Some women who are concerned about their breast secretions may be exacerbating the problem. They do so by pinching their nipples repeatedly to look for nipple discharge. In some cases, letting the nipples alone for a while may aid in the improvement of the problem.

Your doctor will assess if your nipple discharge is normal (physiologic) or abnormal based on your medical history (pathologic). Even if your doctor concludes that your breast discharge is abnormal, bear in mind that the majority of pathological illnesses that produce nipple discharge are mild and treatable.

It is never natural to have a bloody nipple discharge. Nipple discharge from only one breast and discharge that happens without anything touching, stimulating, or aggravating your breast are further symptoms of abnormalities.

When determining whether a discharge is normal or pathological, colour isn’t always useful. The colour of nipple discharge might be clear, yellow, white, or green in both pathological and normal cases.
Nipple discharge can be clear, yellow, white, or green in colour, depending on whether it is pathological or typical.

When the nipples are crushed or pinched, normal nipple discharge is more likely to occur in both nipples. Some women who are worried about their breast secretions may make things worse. Squeezing their nipples frequently to check for nipple discharge is how they do it. Leaving the nipples alone for a while may help the condition improve in certain cases.

What might be the source of normal nipple discharge?

Normal nipple discharge can be caused by a variety of factors, including:

Pregnancy: Some women detect clear breast discharge from their nipples in the early stages of pregnancy. This discharge may become watery and milky in the latter stages of pregnancy.

Breastfeeding is being discontinued: Even after you’ve stopped feeding your infant, you could discover that a milky breast flow lingers.

Stimulation: When the nipples are aroused or pressed, they may release fluid. When your nipples are continually chafed by your bra or during severe physical activity, such as jogging, normal nipple discharge might develop.

March 19, 2022 0 comment

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Alzheimer’s and Women, study finds new evidence

by Medically Speaking March 4, 2022

written by Medically Speaking

Women are twice as likely as males to get Alzheimer’s disease (AD), according to epidemiological research, although the origin of this occurrence is unknown. However, a recent research may offer the answers. The research was published in the scientific journal ‘Nature.’

Alzheimer’s is a condition in which a person gradually forgets what they know. It is a painful punishment, both for those who are subjected to it and for those who are responsible for their care.

Prof. Keqiang Ye of the Chinese Academy of Sciences’ Shenzhen Institute of Advanced Technology (SIAT) conducted the investigation, which offered a clear explanation to a question that has perplexed mankind for decades.
Prof. Ye’s team created the notion that the C/EBPb/AEP pathway was the central mechanism driving the development of neurodegenerative disorders by combining their prior findings.

“Based on this theory, our team searched for female hormones that are dramatically changed during menopause and tested which hormone selectively activates the C/EBPb/AEP pathway,” said Prof.

The key pathogenic component found by Prof. Ye’s team was follicle-stimulating hormone (FSH).

“FSH levels in the blood rise dramatically during menopause, attaching to the corresponding FSH receptor on neurons and activating the C/EBPb/AEP pathway. This resulted in Ab and Tau pathologies, which eventually led to the development of Alzheimer’s disease “Dr. Zaidi Mone, a tenured professor at the Mount Sinai School of Medicine in New York, is a co-corresponding author of the study.
To prove their point, the researchers used a variety of ways. They employed anti-FSH antibody therapy on ovariectomized mice to block FSH and inactivate the C/EBPb/AEP pathway. They also knocked down the expression of the FSH receptor (FSHR) in neurons, which prevented FSH from binding to FSHR in the hippocampus. Both of these approaches were successful in reducing disease and cognitive impairment.

In addition, knockdown of C/EBPb in the AD mice model decreased AD pathologies.

The researchers administered FSH into male mice as well as female mice, and observed that FSH enhanced AD symptoms.

All of these data showed that after menopause, elevated FSH binds to FSHR in neurons and activates the C/EBPb/AEP pathway, which is involved in the onset of AD pathogenesis.

The researchers will investigate why female ApoE4 carriers are more sensitive to developing AD in the near future by examining the interaction between particular risk genes like as ApoE4 and FSH.

“Our findings show that the C/EBPb/AEP signalling pathway is a key player in various age-related disorders, which might lead to a better understanding of how a range of risk factors impact neurodegenerative diseases by activating this pathway,” stated Emory University’s Dr. Seong Su Kang.

Prof. Ye’s team has also applied this idea to a variety of age-related chronic disorders, including diabetes, atherosclerosis, cancer, and ageing.

March 4, 2022 0 comment

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Nightfall: a physiological phenomenon!

by Medically Speaking November 9, 2021

written by Medically Speaking

A nightfall, also known scientifically as a nocturnal emission and colloquially as a wet dream, sex dream, or sleep orgasm, is a spontaneous orgasm that occurs during sleep and involves ejaculation for males and vaginal wetness or an orgasm (or both) for females.

Men can wake up or simply sleep through a wet dream, but for women, several researchers have stipulated that she must awaken during the orgasm and perceive that the orgasm occurred before it counts as a wet dream. The presence of vaginal wetness does not automatically imply that the woman has had an orgasm.

Nocturnal emission is not to be confused with nocturnal tumescence of the penis in men or clitoris in women. Nocturnal penile or clitoral tumescence is the spontaneous erection of the penis or clitoris during sleep or when you wake up from it, and is essentially a sleep-related erection. It occurs usually three to five times during rapid eye movement (REM) sleep and is said to contribute to the penile (or clitoral) health of the individual.

Is Nightfall Normal?

The most common period for nocturnal emissions is during adolescence and early young adulthood, but they can occur at any age after puberty. Scientists suggest that the process of nightfall is completely physiological.

However, rarely, excessive nightfall can be problematic and might require treatment. Excessive masturbation, fluctuating hormone levels, thinning of semen viscosity, and a full bladder aggravate the issue by weakening the penile nerves and muscles. Men may retain their sperm, but the excess is discharged at night.

Dizziness, insomnia, weaker sexual incapacity, erectile dysfunction, knee pain, stress, infertility, and loss of sight and memory are all symptoms of daily nightfall in men. Urine may also accompany the sperm in a few cases.

Why Nightfall Happens?

Nightfall is an extremely common phenomenon that has been proven scientifically to have been experienced by the majority population of men at least once in their lives. Some males have had a high number of nocturnal emissions as juveniles, although others have never had one.

Nocturnal emissions are also more common in some parts of the world. 83 percent of men in the United States have experienced nightfall at some point in their lives. In Indonesia, surveys show that by the age of 24, 97 percent of men have experienced nightfall.

How Frequently is it Okay to Have Nightfall?

Men and women indicated that approximately 8% of their daily dreams involve some kind of sexual-related behavior in a comprehensive study. Orgasms were experienced in 4% of both men and women’s sex dreams.

Frequency in Men

The frequency of nocturnal emissions varies tremendously.

Some say it’s because they’ve been sexually inactive for 1–2 weeks and haven’t engaged in either intercourse or masturbation.

The frequency of experiencing nightfall in men usually decreases with age and/or with marriage, according to studies.

Some males experience emissions only after puberty, while others experience them during their lives. No definitive relation has been established between the frequency of nocturnal emissions and the frequency of masturbation.

The amount of nocturnal emissions a man has is influenced by whether or not he uses testosterone-based medications. A study found that as testosterone levels were raised, the number of boys reporting nocturnal emissions increased dramatically, from 17 percent of subjects with no medication to 90 percent of subjects at a high dose.

Nightfall causes 13% of males to have their first ejaculation. According to a study, males who had their first ejaculation through nocturnal emission were older than those who had their first ejaculation through masturbation.

Frequency in Women

Similar to the findings in males, the frequency of nocturnal emissions varies in women too.

A study discovered that almost 40% of the women interviewed had experienced one or more nocturnal orgasms or wet dreams. Those who claimed they had them said they happened many times a year, that they started as early as 13, and that they normally happened by the age of 21.

Female nocturnal orgasm is characterized as sexual arousal during sleep that awakens one to perceive orgasm.

According to another study, by the age of 21, up to 85 percent of women have experienced nocturnal orgasm. This study was focused on women who awoke with or after orgasm.

Males have more spontaneous nocturnal sexual encounters than females, according to studies. Since ejaculation is commonly associated with male orgasm, while vaginal lubrication does not mean orgasm, female wet dreams may be more difficult to classify with certainty than male wet dreams.

Myths and facts

There are many myths about wet dreams, one of which is that it reduces a man’s sperm count. Here are some more wet dream myths and facts:

A wet dream, also known as a sex dream or a sleep orgasm, is a spontaneous orgasm that occurs while sleeping.
It can cause ejaculation (or cumming) in men and vaginal wetness or an orgasm (or both) in women.
This condition is known medically as nocturnal emission.
Wet dreams are most common during adolescence and early young adulthood, but they can happen at any age after puberty.
Wet dreams are a normal part of puberty and sexual maturation.
There could be two reasons for this: increased levels of sex hormones or increased blood flow to the sexual organs while sleeping.

Lucid Dreams

The theme of sexual activity is popular in lucid dreaming.

LaBerge, Greenleaf, and Kedzierski (1983) conducted a pilot study to see how physiological responses to sexual activity during REM lucid dreaming mirrored subjectively perceived sexual activity.

Her vaginal muscle activity, vaginal pulse amplitude, and respiration rate reached their highest values of the night during the fifteen-second segment of the female subject’s physiological record, which she signaled as the moment of orgasm, and they were also significantly elevated in comparison to the rest of the REM era. Heart rate rose just marginally, contrary to expectations.

Composition of Discharged Fluid

Few studies have looked at the composition of ejaculate produced during nocturnal emissions due to the difficulty in collecting it.

The semen concentration was equal in the largest analysis, which included nocturnal emission samples from 10 men, to samples collected from the same men by penile vibratory stimulation, though the proportions of mobile and normal morphology sperm were higher in the nocturnal emission specimens.

How to Prevent Nightfall?

As stated earlier in this article, it is completely alright physiologically to experience a single or even multiple episodes of nightfall as a man or woman. There are no physical damages that can be positively attributed to nightfall with scientific proof.

However, if the fact that experiencing nocturnal emissions makes you uncomfortable mentally, we suggest you speak to your psychiatrist about it. A detailed discussion with your psychiatrist and related counselling should help you tremendously in overcoming such stigma.

How to Stop Nightfall Completely

The easiest way to get rid of excessive nightfall issues is to see a trained urologist. However, patients should first seek to alter their lifestyle. Meditation, which helps control inner emotions and improves focus, is a natural way to minimize nightfall. Men do not encounter nightfall as long as they are disturbed by unnecessary events.

Yoga and exercise are powerful tools for regaining control of one’s body, mind, and spirit. Nightfall can be stopped by engaging in these exercises on a daily basis. Bathing with essential oils before bedtime will help you sleep better at night because it relaxes both your mind and body.

The Concluding Note

On nightfall, there are many cultural and religious perspectives.

During recent times, society as a whole has come to accept the fact that nightfall is a physiological phenomenon experienced by both men and women in varying frequency and age. Education on the topic via internet articles such as this or by other means have made people more accepting of such phenomena earlier considered taboo and vile.

November 9, 2021 0 comment

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