Early Signs Of Kidney Disease: If you see any difference in your urine, then understand that you have a kidney problem. In such a situation, you should immediately become alert and contact a doctor. Watch the video till the end for information about every disease related to kidney.

Your kidneys are silent but mighty organs, playing a vital role in filtering waste products, regulating blood pressure, and producing hormones essential for overall health. Unfortunately, kidney disease often progresses unnoticed until later stages, making early detection crucial. This article delves into the subtle signs your body might be sending, helping you identify potential kidney problems before they become serious.

Why Early Detection Matters

The kidneys are incredibly adaptable, and even with reduced function, they can often compensate for a while. However, if left unchecked, kidney disease can progress to kidney failure, requiring dialysis or a transplant. Early detection allows for intervention that can slow the progression of the disease and improve your overall health outcomes.

Beyond Changes in Urine: A Spectrum of Early Signs

While changes in urine are a significant indicator, kidney disease can manifest in various ways. Here’s a breakdown of some early signs to be aware of:

Changes in Urination Habits:
- Frequency: An increased need to urinate, especially at night, could signal that your kidneys are struggling to retain fluids effectively.
- Urgency: Feeling a sudden and urgent need to urinate can also be a sign of kidney dysfunction.
- Difficulty Urinating: Straining or having difficulty passing urine could indicate a blockage or other kidney problems.
Changes in Urine Appearance:
- Blood in Urine (Hematuria): The presence of blood in your urine, even if microscopic, can be a sign of kidney damage.
- Foamy Urine: Excessive bubbles in your urine can indicate the presence of protein, which healthy kidneys typically don’t allow to pass through.
- Cloudy or Discolored Urine: Cloudy urine can be a sign of infection, while changes in color, like brown or red, could indicate bleeding or other problems.
General Changes in Well-Being:
- Fatigue and Weakness: Anemia, a common complication of kidney disease, can lead to fatigue and a general lack of energy.
- Swelling: Fluid retention, a consequence of impaired kidney function, can cause puffiness around the eyes, ankles, or feet.
- High Blood Pressure: Kidney problems can contribute to high blood pressure, which can further damage the kidneys, creating a vicious cycle.
- Loss of Appetite and Nausea: Waste products that healthy kidneys typically remove can build up in the blood, leading to nausea and loss of appetite.
- Trouble Sleeping: Urinary frequency at night can disrupt sleep, and feelings of unease due to underlying health concerns can further contribute to sleep problems.
- Skin Problems: Dry, itchy skin can be a sign of mineral and electrolyte imbalances caused by kidney dysfunction.
- Trouble Concentrating: Anemia and waste product buildup in the blood can affect cognitive function, leading to difficulty concentrating.

It’s Not Just About Urine: Risk Factors to Consider

While changes in urination are important indicators, certain risk factors increase your chances of developing kidney disease. Being aware of these can help you prioritize early detection:

Diabetes: High blood sugar levels can damage the delicate blood vessels in the kidneys.
High Blood Pressure: Uncontrolled high blood pressure can put a strain on the kidneys.
Family History: Having a family member with kidney disease increases your risk.
Age: The risk of kidney disease increases with age.
Certain Medications: Long-term use of some pain medications and antibiotics can harm the kidneys.
Lifestyle Habits: Smoking, obesity, and a diet high in sodium and protein can contribute to kidney problems.

Don’t Wait for the Video to End: Take Action Now

Early detection is key to managing kidney disease effectively. If you experience any of the signs mentioned above, especially if you have any risk factors, don’t hesitate to schedule an appointment with your doctor. Early diagnosis can lead to treatment that can slow the progression of the disease and improve your quality of life.

Here are some additional steps you can take to promote kidney health:

Maintain a healthy weight: Losing weight if you’re overweight can help reduce stress on your kidneys.
Eat a healthy diet: Focus on a balanced diet that’s low in sodium and protein, with plenty of fruits, vegetables, and whole grains.
Manage blood pressure: Work with your doctor to keep your blood pressure under control.
Control blood sugar: If you have diabetes, it’s crucial to manage your blood sugar levels to prevent kidney damage.
Stay hydrated: Drinking plenty of water helps your kidneys function optimally.
Limit alcohol and smoking: These habits can harm your kidneys.

A novel cell therapy trial for individuals with diabetes has produced encouraging results, according to researchers. The NEPHSTROM clinical research is starting to look at the possibility of a novel cell therapy to treat persons with type 2 diabetes who are still experiencing kidney impairment after getting extensive medical care. At the American Society of Nephrology’s Kidney Week conference in Orlando, Florida, the findings of the NEPHSTROM clinical study were presented in November. It demonstrated that a single intravenous dosage of ORBCEL-M was safe and linked with greater renal function preservation than a placebo when administered to carefully chosen persons with progressive kidney disease owing to diabetes.

After receiving ORBCEL-M, study participants were continuously monitored for an additional 18 months. Orbsen Therapeutics Ltd., a spinout firm from the University of Galway, discovered and developed the ORBCEL-M cell treatment in Galway using mesenchymal stromal cells (MSC) prepared from healthy bone marrow. The Mario Negri Institute for Pharmacological Research IRCCS in Bergamo, Italy, is overseeing the clinical trial, which is being conducted in collaboration with top medical facilities in Galway, Bergamo, Birmingham, and Belfast.

Professor Matt Griffin, the trial’s principal investigator and a consultant nephrologist at Galway University Hospitals’ Regenerative Medicine Institute (REMEDI), said: “In Ireland, there are close to a quarter of a million diabetics, and we know that more than 40% of them have kidney disease, also known as diabetic kidney disease or DKD.

“In type 2 diabetes, as many as one-third of those with DKD have worsening kidney function despite the best medical therapy we can offer. These people are at high risk for requiring dialysis or kidney transplantation in the years ahead – both of which are complex treatments with potentially serious complications.

“In NEPHSTROM, our goal is to secure evidence that a cell therapy, such as ORBCEL-M, is safe and can slow the course of DKD to help more people with diabetes avoid the need for dialysis or transplantation. It was exciting to report that our first analysis of results from the trial supports that goal.”

Dr Steve Elliman, who discovered the ORBCEL-M therapy, is Chief Scientific Officer for Orbsen Therapeutics. Dr Elliman said: “At Orbsen Therapeutics we are motivated by improving patient care. Diabetic patients with progressive kidney disease eventually require dialysis and often a kidney transplant. While dialysis improves the quality of life of patients with kidney failure, it is expensive and does not prevent further decline of kidney function.

Additionally, dialysis takes four hours per session and three times a week – creating logistic and economic challenges for the patient. Our goal with ORBCEL-M is to resolve systemic inflammation and improve kidney function, so that patients will not require dialysis or a kidney transplant. We’re encouraged by the safety profile and the preliminary efficacy signals in patients with DKD reported by the NEPHSTROM trial. We look forward to continued collaboration with our University of Galway and NEPHSTROM partners to advance this new medicine through Phase 3 efficacy trials and a market approval.”

Dr Veronica McInerney, Administrative Director at the HRB Clinical Research Facility at University of Galway said: “Without patient involvement in clinical trials, advances in new treatments are simply not possible. We are fortunate to have the HRB Clinical Research Facility Galway, a clinically equipped space to see and treat patients on trials. We are hopeful that future generations will benefit from the willingness of patients to participate in trials, such as the NEPHSTROM trial.”

Professor Timothy O’Brien, Director of the Regenerative Medicine Institute (REMEDI), at the University of Galway and Consultant Physician in Endocrinology at Galway University Hospitals and the overall lead of the NEPHSTROM project, said: “University of Galway’s ecosystem is set up to facilitate and lead international trials of this nature.

The Cell Therapy GMP manufacturing facilities at the Centre for Cell Manufacturing Ireland, located in the University, along with the HRB Clinical Research Facility, the close partnership with Saolta University Heath Care Group and REMEDI have been instrumental in making the progression of this potential new therapy possible. Funding from SFI, the Higher Education Authority and the Health Research Board has supported and helped build this ecosystem and along with European Commission funding has made the advancement of this research possible.”

kidney diseases

Silent But Deadly: Unveiling the Early Signs of Kidney Disease (Watch Video for a Complete Guide)

According to researchers, cell treatment may lessen effects of type 2 diabetes on kidney